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Mechanism-Based Biological Inference via Multiplex Networks, AI Agents and Cross-Species Translation
This invention provides a platform that uses AI agents and biological networks to uncover and interpret disease-relevant biological mechanisms.

Enzymes for synthesis of sequenced oligoamide triads and tetrads that can be polymerized into sequenced copolyamides.
Contact
To learn more about this technology, email partnerships@ornl.gov or call 865-574-1051.

We tested 48 diverse homologs of SfaB and identified several enzyme variants that were more active than SfaB at synthesizing the nylon-6,6 monomer.

By engineering the Serine Integrase Assisted Genome Engineering (SAGE) genetic toolkit in an industrial strain of Aspergillus niger, we have established its proof of principle for applicability in Eukaryotes.

US coastal and island communities have vulnerable energy infrastructure and high energy costs, which are exacerbated by climate change.

The invention presented here addresses key challenges associated with counterfeit refrigerants by ensuring safety, maintaining system performance, supporting environmental compliance, and mitigating health and legal risks.

This invention aims to develop a new feature for a heat pump water heater having a forced flow condenser, coupled with a mixing valve, and a new feature to maximize the first hour rating and provide quick response to hot water demand, comparable to a typical gas water heater.&

Estimates based on the U.S. Department of Energy (DOE) test procedure for water heaters indicate that the equivalent of 350 billion kWh worth of hot water is discarded annually through drains, and a large portion of this energy is, in fact, recoverable.

We present a comprehensive muti-technique approach for systematic investigation of enzymes generated by wastewater Comamonas species with hitherto unknown functionality to wards the depolymerization of plastics into bioaccessible products for bacterial metabolism.

The heat exchanger is a three-medium heat exchanger with phase change material (PCM) stored in the external fin tubes. It allows the refrigerant flowing inside the internal fin tubes and the air to