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Technology

Improved Amide Synthetases for Nylon Synthesis

Invention Reference Number

202505894

We tested 48 diverse homologs of SfaB and identified several enzyme variants that were more active than SfaB at synthesizing the nylon-6,6 monomer. The best, identified in the genome of an uncultivated bacterium, is approximately 10-fold more active at synthesizing the nylon-6,6 monomer than SfaB.

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To learn more about this technology, email partnerships@ornl.gov or call 865-574-1051.