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Concept to control the sampling capillary-to-surface distance for use with surface sampling mass spectrometric detection techniques (e.g. DESI, DAPCI, MALDI, etc.) were developed by applying high precision distance measurements using laser sensors.

Software using an image analysis approach was developed to control the sampling capillary-to-surface distance for use with desorption electrospray (DESI) mass spectrometric detection.