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This invention is directed to a machine leaning methodology to quantify the association of a set of input variables to a set of output variables, specifically for the one-to-many scenarios in which the output exhibits a range of variations under the same replicated input condi

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Biocompatible nanoparticles have been developed that can trap and retain therapeutic radionuclides and their byproducts at the cancer site. This is important to maximize the therapeutic effect of this treatment and minimize associated side effects.

ORNL scientists identified four amino acids key to signaling pathways in the PAN protein domain. Mutating any of those disrupted the signal that tells cancer cells to multiply. Credit: Andy Sproles/ORNL, U.S. Dept. of Energy

An ORNL team has developed a method for screening for an immunoregulatory protein, which includes assessing the sequence of a candidate protein to determine if it is an immunoregulatory protein when at least one plasminogen-apple-nematode (PAN) domain with a consensus sequence