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The disclosed technologies are directed to the smart control of a system that integrates underground TES into geothermal heat pumps.

The invention ensures post-validation calibrated physics system predictions remain within predetermined model validation domain boundaries.

An ORNL team has developed a method for screening for an immunoregulatory protein, which includes assessing the sequence of a candidate protein to determine if it is an immunoregulatory protein when at least one plasminogen-apple-nematode (PAN) domain with a consensus sequence