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Genetic modification of microbes that are thermophiles—ones that grow at elevated temperatures—is extremely challenging. Tools developed for E. coli, a typical host for protein production, typically do not function at elevated temperatures.

Ice crystals

The widespread use of inexpensive salt hydrate-based phase change materials, or PCMs, has been prevented by a key technical challenge: phase separation, also known as incongruency, which results in the significant degradation of the materials' ability to store thermal energy o