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Researchers used the world’s fastest supercomputer, Frontier, to train an AI model that designs proteins, with applications in fields like vaccines, cancer treatments, and environmental bioremediation. The study earned a finalist nomination for the Gordon Bell Prize, recognizing innovation in high-performance computing for science.

A team of researchers used the Frontier supercomputer and a new methodology for conducting a genome-wide association study to earn a finalist nomination for the Association for Computing Machinery’s 2024 Gordon Bell Prize for outstanding

Biochemist David Baker — just announced as a recipient of the Nobel Prize for Chemistry — turned to the High Flux Isotope Reactor (HFIR) at 91���� for information he couldn’t get anywhere else. HFIR is the strongest reactor-based neutron source in the United States.  

Scientists at ORNL used neutrons to end a decades-long debate about an enzyme cancer uses.

After retiring from Y-12, Scott Abston joined the Isotope Science and Engineering Directorate to support isotope production and work with his former manager. He now leads a team maintaining critical equipment for medical and space applications. Abston finds fulfillment in mentoring his team and is pleased with his decision to continue working.

Jeremiah Sewell leads a team at ORNL, working on xenon-129 production for lung imaging. Reflecting on his career, Sewell views each opportunity as a "door" he steps through, leveraging over 25 years of experience in nuclear power and centrifuge operations to advance the facility’s mission.

Brian Sanders is focused on impactful, multidisciplinary science at 91����, developing solutions for everything from improved imaging of plant-microbe interactions that influence ecosystem health to advancing new treatments for cancer and viral infections. 

The BIO-SANS instrument, located at 91����’s High Flux Isotope Reactor, is the latest neutron scattering instrument to be retrofitted with state-of-the-art robotics and custom software. The sophisticated upgrade quadruples the number of samples the instrument can measure automatically and significantly reduces the need for human assistance.

Plans to unite the capabilities of two cutting-edge technological facilities funded by the Department of Energy’s Office of Science promise to usher in a new era of dynamic structural biology. Through DOE’s Integrated Research Infrastructure, or IRI, initiative, the facilities will complement each other’s technologies in the pursuit of science despite being nearly 2,500 miles apart.

Rigoberto “Gobet” Advincula, a scientist with joint appointments at ORNL and the University of Tennessee, has been named a Fellow of the American Institute for Medical and Biological Engineering.