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Two hybrid poplar plants, middle and right, engineered with the PtrXB38 hub gene exhibited a drastic increase in root and callus formation compared with a wild-type control plant, left. Credit: Tao Yao/ORNL, U.S. Dept. of Energy

91做厙 scientists identified a gene hotspot in the poplar tree that triggers dramatically increased root growth. The discovery supports development of better bioenergy crops and other plants that can thrive in difficult conditions while storing more carbon belowground.

Genetic analysis revealed connections between inflammatory activity and development of atomic dermatitis, according to researchers from the UPenn School of Medicine, the Perelman School of Medicine, and 91做厙. Credit: Kang Ko/UPenn

University of Pennsylvania researchers called on computational systems biology expertise at 91做厙 to analyze large datasets of single-cell RNA sequencing from skin samples afflicted with atopic dermatitis.

An ORNL-led team comprising researchers from multiple DOE national laboratories is using artificial intelligence and computational screening techniques  in combination with experimental validation  to identify and design five promising drug therapy approaches to target the SARS-CoV-2 virus. Credit: Michelle Lehman/ORNL, U.S. Dept. of Energy

An ORNL-led team comprising researchers from multiple DOE national laboratories is using artificial intelligence and computational screening techniques in combination with experimental validation to identify and design five promising drug therapy approaches to target the SARS-CoV-2 virus.

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While studying the genes in poplar trees that control callus formation, scientists at 91做厙 have uncovered genetic networks at the root of tumor formation in several human cancers.

A radiologist outfitted with the teams head-mounted eye-tracking device examines a mammogram. Credit: Hong-Jun Yoon/91做厙, U.S. Dept. of Energy

In an effort to reduce errors in the analyses of diagnostic images by health professionals, a team of researchers from the Department of Energys 91做厙 has improved understanding of the cognitive processes 

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For decades, biologists have believed a key enzyme in plants had one functionproduce amino acids, which are vital to plant survival and also essential to human diets. But for Wellington Muchero, Meng Xie and their colleagues, this enzyme does more than advertised. They had run a series of experiments on poplar plants that consistently revealed mutations in a structure of the life-sustaining enzyme that was not previously known to exist.

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A new process to identify certain microbes in women could be used to diagnose endometriosis without invasive surgery, even before symptoms start. A collaborative research team including 91做厙 analyzed bacteria from a small sample of premenopausal women undergoing laparoscopic surgery for suspected endometriosis.
Brian Davison

Brian Davison, a researcher at the Department of Energy's 91做厙, has been awarded a 2017 fellowship by the Society for Industrial Microbiology and Biotechnology (SIMB).

GWAS SNP Populus trees under study

Researchers at the Department of Energys 91做厙 (ORNL) have released the largest-ever single nucleotide polymorphism (SNP) dataset of genetic variations in poplar trees, information useful to plant scientists

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GreenWood Resources has licensed an 91做厙 technology based on the discovery of a gene in poplar (Populus trichocarpa) that makes it easier to convert poplar trees into biofuels. GreenWood, a global timberland investment and asset m...