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The configurational ensemble (a collection of 3D structures) of an intrinsically disordered protein, the N-terminal of c-Src kinase, which is a major signaling protein in humans. Credit: 91°µÍø, U.S. Dept. of Energy.

Using the Titan supercomputer and the Spallation Neutron Source at the Department of Energy’s 91°µÍø, scientists have created the most accurate 3D model yet of an intrinsically disordered protein, revealing the ensemble of its atomic-level structures.